Qvist N, Storm K
Acta Obstet Gynecol Scand. 1983;62(2):157-9. doi: 10.3109/00016348309155782.
Twenty patients undergoing cesarean section received cimethidine 400 mg intramuscularly as pre-anesthetic approximately 70 minutes prior to gastric aspiration. The average pH was 5.05, as against 2.97 in the control group (p less than 0.01). No significant reduction in the aspirated volumes was observed. In the cimethidine group the proportion of patients at risk of developing Mendelson's syndrome (pH less than 2.5 and volume greater than 25 ml) was significantly reduced, viz. 5% as against 42% in the control group (P = 0.014). No perinatal effects attributable to cimethidine was observed in the infants. Hence, cimethidine is a safe and useful pre-anesthetic for patients undergoing cesarean section, irrespective of indication and, consequently, much to be preferred to oral antacids.
20例行剖宫产术的患者在术前约70分钟接受400毫克西咪替丁肌肉注射。平均pH值为5.05，而对照组为2.97（p<0.01）。未观察到抽吸量有显著减少。在西咪替丁组中，发生门德尔森综合征风险的患者比例（pH值<2.5且量>25毫升）显著降低，即5%，而对照组为42%（P=0.014）。在婴儿中未观察到归因于西咪替丁的围产期影响。因此，西咪替丁对于行剖宫产术的患者而言是一种安全且有用的麻醉前用药，无论其手术指征如何，因而远比口服抗酸剂更可取。
