Kato S, Kimura M, Tsuji K, Kusakawa S, Asai T, Juji T, Kawasaki T
Pediatrics. 1978 Feb;61(2):252-5.
Two hundred five patients with Kawasaki disease and 500 normal controls were HLA-typed, using a standard microcytotoxicity test of tissue typing. HLA-BW22 was more common in patients with Kawasaki disease than in normal controls (25.4% instead of 11.8%, corrected P less than .0005). Among subtypes of HLA-BW22 antigen, Kawasaki disease was associated with HLA-BW22J2, which was found specifically in Japanese and not in Caucasians. These facts may suggest that there is a gene controlling the susceptibility to Kawasaki disease and linked with a Japanese-specific HLA antigen.
采用标准的组织分型微量细胞毒性试验，对205例川崎病患者和500名正常对照者进行了HLA分型。HLA - BW22在川崎病患者中比在正常对照者中更为常见（分别为25.4%和11.8%，校正P值小于0.0005）。在HLA - BW22抗原的亚型中，川崎病与HLA - BW22J2相关，后者仅在日本人中发现，而在白种人中未发现。这些事实可能提示存在一个控制川崎病易感性并与日本特异性HLA抗原连锁的基因。
