盐摄入对清醒犬肾压力感受器的影响及其在控制血浆肾素活性中的作用

Alteration of renal baroreceptor by salt intake in control of plasma renin activity in conscious dogs.

作者信息

Farhi E R, Cant J R, Barger A C

出版信息

Am J Physiol. 1983 Jul;245(1):F119-22. doi: 10.1152/ajprenal.1983.245.1.F119.

DOI:10.1152/ajprenal.1983.245.1.F119

Abstract

We investigated the relationship between renal arterial pressure (RAP) and systemic plasma renin activity (PRA) in five uninephrectomized conscious dogs on normal salt (80 meq Na+/day) and low salt (10 meq Na+/day) diets. The RAP was controlled by an inflatable cuff placed around the origin of the renal artery. In both salt states the PRA was an exponential function of the RAP: log (PRA) = (-0.026 X RAP) + 2 on the normal salt diet (r = 0.96) and log (PRA) = (-0.026 X RAP) + 2.5 on the low salt diet (r = 0.99). At any RAP, the value of the low salt PRA was 3 times that of the normal salt PRA. Accordingly, a reduction in salt intake increases the sensitivity of the renal baroreceptor so that the absolute value of PRA increases at any RAP, but the percentage change in PRA caused by any change in RAP is the same in both normal and low salt states.

摘要

我们在五只接受单侧肾切除的清醒犬身上研究了肾动脉压（RAP）与全身血浆肾素活性（PRA）之间的关系，这些犬分别处于正常盐摄入（80 毫当量钠/天）和低盐摄入（10 毫当量钠/天）饮食状态。通过围绕肾动脉起始部放置的可充气袖带控制 RAP。在两种盐摄入状态下，PRA 均为 RAP 的指数函数：在正常盐饮食时，log（PRA）=（-0.026×RAP）+2（r = 0.96）；在低盐饮食时，log（PRA）=（-0.026×RAP）+2.5（r = 0.99）。在任何 RAP 水平下，低盐状态下的 PRA 值是正常盐状态下的 3 倍。因此，盐摄入量的减少会增加肾压力感受器的敏感性，使得在任何 RAP 时 PRA 的绝对值增加，但在正常和低盐状态下，由 RAP 的任何变化引起的 PRA 百分比变化是相同的。