Beauvillain de Montreuil C, Lajat Y, Resche F, Boutet J J, Legent F
Ann Otolaryngol Chir Cervicofac. 1983;100(3):181-6.
Mesencephalic tractotomy employing the stereotaxic method was conducted 12 times in 11 patients with pain due to cervicofacial cancer only partially relieved by high doses of opiates. Immediate results were spectacular in 10 cases and partial on the other 2 occasions. However, relief was not permanent even in patients in whom the greatest improvement was obtained, and the usual analgesics had to be prescribed after 3 months. The operation, which requires only a short period of anesthesia, was always well supported, complications being anesthesia of one side of the body in 2 patients and convergence paralysis in two cases, one of which was transient. Mesencephalic tractotomy constitutes a new weapon for the treatment of diffuse cervicofacial cancer pain not responding to major medical treatment. Elective thermocoagulation of the Vth and IXth nerves was also successfully employed for systematized pains.
采用立体定向方法对11例因头面部癌症疼痛且大剂量阿片类药物仅部分缓解的患者进行了12次中脑束切断术。10例患者的即时效果显著,另外2例部分有效。然而,即使是改善最明显的患者,疼痛缓解也不是永久性的,3个月后仍需使用常规镇痛药。该手术仅需短暂麻醉,患者耐受性良好,2例患者出现身体一侧麻醉,2例出现会聚性麻痹,其中1例为暂时性。中脑束切断术为治疗对主要药物治疗无反应的弥漫性头面部癌症疼痛提供了一种新手段。选择性热凝第Ⅴ和第Ⅸ神经也成功用于系统性疼痛的治疗。