人类对腮腺炎抗原的迟发型超敏反应。

Delayed hypersensitivity to mumps antigen in humans.

作者信息

Callaghan J T, Petersen B H, Smith W C, Epinette W W, Ransburg R C

出版信息

Clin Immunol Immunopathol. 1983 Jan;26(1):102-10. doi: 10.1016/0090-1229(83)90178-2.

Abstract

Sixty-one subjects, preselected for mumps sensitivity, were entered into a double-blind protocol to standardize Mumps Skin Test Antigen. Four lots of mumps antigen selected on the basis of in vitro potency tests were used. Four other antigens, Histoplasmin, Dermatophytin-O, Dermatophytin, and fluid tetanus toxoid were also tested; positive reactions for these four antigens occurred in 48, 68, 25, and 43% of individuals, respectively. The mumps lots exhibited delayed hypersensitivity with positivity ranging from 63 to 67% at 20 CFU/ml and 77 to 84% at 80 CFU/ml in the acceptable lots. Side effects were primarily local and minor in nature. Mumps Skin Test Antigen is a useful measure of the integrity of the immune system, but lacks complete specificity because of local dermal factors.

摘要

61名预先筛选出对腮腺炎敏感的受试者进入双盲试验方案，以标准化腮腺炎皮肤试验抗原。使用了根据体外效价试验挑选出的4批腮腺炎抗原。还对其他4种抗原进行了测试，分别是组织胞浆菌素、皮肤真菌素 - O、皮肤真菌素和液体破伤风类毒素；这4种抗原的阳性反应分别出现在48%、68%、25%和43%的个体中。在可接受的批次中，腮腺炎批次表现出迟发型超敏反应，在20 CFU/ml时阳性率为63%至67%，在80 CFU/ml时为77%至84%。副作用主要是局部的，且性质轻微。腮腺炎皮肤试验抗原是免疫系统完整性的一项有用指标，但由于局部皮肤因素而缺乏完全特异性。