Bennett A, Wilson D M, Liu F, Nagashima R, Rosenfeld R G, Hintz R L
J Clin Endocrinol Metab. 1983 Sep;57(3):609-12. doi: 10.1210/jcem-57-3-609.
Levels of insulin-like growth factors I and II (IGF-I and IGF-II) and somatomedin peptide content (SMPC) were measured in 32 normal term and 11 preterm infants. After acid chromatography to remove somatomedin-binding protein, SMPC was measured by placental membrane radioreceptor assay, while plasma IGF-I and II concentrations were measured by specific RIAs. SMPC levels in term infants were significantly below normal adult levels [0.49 +/- 0.13 (+/- SD) U/ml for infants compared to 1.30 +/- 0.25 U/ml for adult males]. IGF-I levels in term infants were also low, averaging 113 +/- 35 ng/ml for infants; the normal adult levels is 184 +/- 32 ng/ml. The IGF-II level was 282 +/- 84 ng/ml for infants and 687 +/- 169 ng/ml for adults. Both IGF-I and II levels in preterm infants were lower than those in term infants. IGF-I, and IGF-II, and SMPC levels showed a positive correlation with birth weight in term infants. Both IGF-I and IGF-II levels showed a strong positive correlation with gestational age in all infants.
对32名足月正常婴儿和11名早产婴儿的胰岛素样生长因子I和II（IGF-I和IGF-II）水平以及生长调节素肽含量（SMPC）进行了测量。经酸色谱法去除生长调节素结合蛋白后，采用胎盘膜放射受体分析法测量SMPC，同时采用特异性放射免疫分析法测量血浆IGF-I和II浓度。足月婴儿的SMPC水平显著低于正常成人水平[婴儿为0.49±0.13（±标准差）U/ml，而成人男性为1.30±0.25 U/ml]。足月婴儿的IGF-I水平也较低，婴儿平均为113±35 ng/ml；正常成人水平为184±32 ng/ml。婴儿的IGF-II水平为282±84 ng/ml，成人为687±169 ng/ml。早产婴儿的IGF-I和II水平均低于足月婴儿。足月婴儿的IGF-I、IGF-II和SMPC水平与出生体重呈正相关。在所有婴儿中，IGF-I和IGF-II水平均与胎龄呈强正相关。
