Quabbe H J, Trompke M, Luyckx A S
J Clin Endocrinol Metab. 1983 Sep;57(3):613-8. doi: 10.1210/jcem-57-3-613.
The influence of ketone body infusion on the serum GH and glucagon response to FFA depression and insulin hypoglycemia was investigated in 10 healthy men. Intravenous infusion of nicotinic acid induced suppression of both FFA and ketone bodies. This was accompanied by a delayed GH increase to 21.1 +/- 6.9 ng/ml (at 300 min). During an additional beta-hydroxybutyrate (OHB) infusion, FFA remained depressed, but ketone bodies were elevated, and the GH response was abolished (maximum 5.6 +/- 1.6 ng/ml). During infusion of OHB alone, FFA were suppressed. GH increased significantly, although less markedly than during suppression of both FFA and ketone bodies (to 9.3 +/- 3.1 ng/ml at 270 min). No GH rise occurred when both FFA and ketone bodies were kept elevated by the addition of a lipid infusion. The GH rise in response to insulin hypoglycemia was not changed by an OHB infusion (43.2 +/- 4.6 vs. 48.0 +/- 7.3 ng/ml). However, OHB increased the net GH output by significantly delaying the return to basal concentrations in the presence of a reduced FFA rebound. An effect of OHB infusion on the plasma glucagon concentration during all experiments was small, and its physiological significance is doubtful. These results confirm that FFA depression induces delayed GH secretion. They suggest that this is not wholly dependent on concomitant depression of ketone bodies. On the other hand, when ketone bodies are elevated, the GH response to FFA depression is diminished or absent. The net GH response to changes in lipid substrates probably depends on the concentration of both FFA and ketone bodies.
在10名健康男性中研究了酮体输注对血清生长激素（GH）以及对游离脂肪酸（FFA）降低和胰岛素低血糖反应时胰高血糖素的影响。静脉输注烟酸可导致FFA和酮体均受到抑制。这伴随着GH延迟升高至21.1±6.9 ng/ml（在300分钟时）。在额外输注β-羟基丁酸（OHB）期间，FFA仍处于降低状态，但酮体升高，且GH反应消失（最高为5.6±1.6 ng/ml）。单独输注OHB期间，FFA受到抑制。GH显著升高，尽管不如FFA和酮体均受抑制时明显（在270分钟时升至9.3±3.1 ng/ml）。当通过输注脂质使FFA和酮体均保持升高时，未出现GH升高。OHB输注并未改变GH对胰岛素低血糖的反应（分别为43.2±4.6 ng/ml和48.0±7.3 ng/ml）。然而，在FFA反弹降低的情况下，OHB通过显著延迟恢复至基础浓度而增加了GH的净输出量。在所有实验中，OHB输注对血浆胰高血糖素浓度的影响较小，其生理意义尚不确定。这些结果证实FFA降低会诱导GH分泌延迟。它们表明这并非完全依赖于酮体的同时降低。另一方面，当酮体升高时，GH对FFA降低的反应减弱或消失。GH对脂质底物变化的净反应可能取决于FFA和酮体的浓度。
