Rakita L, Sobol S M
JAMA. 1983 Sep 9;250(10):1293-5.
Large initial doses of amiodarone hydrochloride for the treatment of ventricular arrhythmias refractory to conventional therapy were demonstrated to shorten the time to achieve control of the arrhythmia. As compared with a lower-dose regimen, the mean time to achieve partial control (suppression of ventricular tachycardia) was 10.6 +/- 5.2 days in the highest-dose group (group C), 9.5 +/- 6.4 days in the medium-dose group (group B), and 16.9 +/- 9.1 days in the lowest-dose group (group A). Complete control (suppression of virtually all ventricular ectopy) was similarly earlier in groups B and C (16.1 +/- 7.5 days and 16.0 +/- 11.3 days, respectively) as compared with group A (31.0 +/- 10.1 days). The final mean dose for long-term treatment was independent of the initial dose schedule (551 +/- 245 mg/day; range, 200 to 1,200 mg/day). The large doses were shown to be well tolerated and without serious side effects.
已证实，大剂量初始使用盐酸胺碘酮治疗对传统疗法难治的室性心律失常，可缩短实现心律失常控制的时间。与低剂量方案相比，高剂量组（C组）实现部分控制（室性心动过速抑制）的平均时间为10.6±5.2天，中剂量组（B组）为9.5±6.4天，低剂量组（A组）为16.9±9.1天。与A组（31.0±10.1天）相比，B组和C组实现完全控制（几乎所有室性早搏抑制）的时间同样更早（分别为16.1±7.5天和16.0±11.3天）。长期治疗的最终平均剂量与初始剂量方案无关（551±245毫克/天；范围为200至1200毫克/天）。大剂量显示耐受性良好且无严重副作用。
