Chanal M, Sirot J, Cluzel M, Joly B, Glanddier Y
Pathol Biol (Paris). 1983 Jun;31(6):467-70.
Temocillin is a carboxypenicillin; a methoxy group in the 6-alpha position should confer to the molecule greater stability to beta-lactamases. 236 strains isolated from clinical specimens were tested. MICs were determined by agar dilution method. Enterobacteriaceae were very susceptible, MICs being generally less than or equal to 8 micrograms/ml and always less than 32 micrograms/ml. The activity of the drug was equal against the beta-lactamases producing strains. On the other hand temocillin was not active against aerobes (Pseudomonas aeruginosa and 90% of Acinetobacter), and against Gram positive bacteria. The bactericidal effect was strong: (formula; see text) A regression-line was proposed for Enterobacteriaceae and "break-points" were discussed.
替莫西林是一种羧基青霉素；6-α位的甲氧基应赋予该分子对β-内酰胺酶更高的稳定性。对从临床标本中分离出的236株菌株进行了测试。通过琼脂稀释法测定最低抑菌浓度（MIC）。肠杆菌科细菌非常敏感，MIC一般小于或等于8微克/毫升，且始终小于32微克/毫升。该药物对产β-内酰胺酶菌株的活性相同。另一方面，替莫西林对需氧菌（铜绿假单胞菌和90%的不动杆菌）以及革兰氏阳性菌无活性。杀菌作用很强：（公式；见正文）提出了肠杆菌科细菌的回归线并讨论了“断点”。
