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使用乙酰唑胺(醋氮酰胺)导致的急性肾衰竭。

Acute renal failure from the use of acetazolamide (Diamox).

作者信息

Higenbottam T, Ogg C S, Saxton H M

出版信息

Postgrad Med J. 1978 Feb;54(628):127-8. doi: 10.1136/pgmj.54.628.127.

DOI:10.1136/pgmj.54.628.127
PMID:634875
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2425061/
Abstract

The clinical histories of two patients are presented, who both developed haemorrhagic anuria after a short course of therapy with the carbonic anhydrase inhibitor, acetazolamide (Diamox). The clinical findings, in particular the radiological changes, are illustrated in this potentially fatal condition. The therapeutic success of immediate relief of the ureteric obstruction is emphasized and it is hoped that this report will act as a reminder of the importance of this agent as a cause of anuria.

摘要

本文介绍了两名患者的临床病史,他们在短期使用碳酸酐酶抑制剂乙酰唑胺(醋氮酰胺)治疗后均出现出血性无尿。本文展示了这种潜在致命疾病的临床发现,尤其是放射学变化。强调了立即缓解输尿管梗阻的治疗成功,并希望本报告能提醒人们注意该药物作为无尿原因的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c0d/2425061/39d2f72a0072/postmedj00254-0068-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c0d/2425061/4eee8157af21/postmedj00254-0067-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c0d/2425061/39d2f72a0072/postmedj00254-0068-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c0d/2425061/4eee8157af21/postmedj00254-0067-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c0d/2425061/39d2f72a0072/postmedj00254-0068-a.jpg

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1
Acute renal failure from the use of acetazolamide (Diamox).使用乙酰唑胺(醋氮酰胺)导致的急性肾衰竭。
Postgrad Med J. 1978 Feb;54(628):127-8. doi: 10.1136/pgmj.54.628.127.
2
Phenacetin-induced renal papillary necrosis: pyonephros, anuria, and bilateral ureteral obstruction.非那西丁引起的肾乳头坏死:脓性肾积水、无尿和双侧输尿管梗阻。
Urology. 1975 Jun;5(6):780-3. doi: 10.1016/0090-4295(75)90353-2.
3
[Anuric acute renal failure due to acetazolamide].乙酰唑胺所致无尿性急性肾衰竭
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[Diamox and manifestation of diabetes mellitus].[乙酰唑胺与糖尿病表现]
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Tamm-Horsfall protein accumulation in glomeruli during acetazolamide-induced acute renal failure.乙酰唑胺诱导的急性肾衰竭期间肾小球中Tamm-Horsfall蛋白的积聚
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Acetazolamide therapy with renal complications.伴有肾脏并发症的乙酰唑胺治疗
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An Unusual Case of Anuric Acute Kidney Injury Secondary to the Use of Low-Dose Acetazolamide as Preventive Management for Acute Mountain Sickness.一例罕见的无尿性急性肾损伤病例,继发于使用低剂量乙酰唑胺作为急性高原病的预防性治疗。
Diseases. 2025 Jul 21;13(7):228. doi: 10.3390/diseases13070228.
2
Ocular and Systemic Factors Associated with Glaucoma.与青光眼相关的眼部及全身因素。
J Curr Glaucoma Pract. 2022 Sep-Dec;16(3):179-191. doi: 10.5005/jp-journals-10078-1383.
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Acetazolamide-Associated Acute Kidney Injury in Critically Ill Pediatric Patients.

本文引用的文献

1
Twenty-nine children with sulphonamide haematuria.29例磺胺类药物所致血尿患儿。
Lancet. 1958 Apr 19;1(7025):826-7. doi: 10.1016/s0140-6736(58)91743-4.
2
Thrombocytopenia and renal lesions associated with acetazoleamide (diamox) therapy.与乙酰唑胺(醋氮酰胺)治疗相关的血小板减少症和肾脏损害。
AMA Arch Intern Med. 1957 Jun;99(6):1006-8. doi: 10.1001/archinte.1957.00260060164013.
3
Renal failure associated with acetazolamide therapy for glaucoma.与乙酰唑胺治疗青光眼相关的肾衰竭。
危重症儿科患者中与乙酰唑胺相关的急性肾损伤
J Pediatr Pharmacol Ther. 2021;26(5):467-471. doi: 10.5863/1551-6776-26.5.467. Epub 2021 Jun 28.
4
Anuric Acute Kidney Injury Requiring Dialysis Following Acetazolamide Use for Cataract Surgery.使用乙酰唑胺进行白内障手术后出现无尿性急性肾损伤并需要透析。
Am J Case Rep. 2021 Apr 23;22:e931319. doi: 10.12659/AJCR.931319.
5
Hemorrhagic Anuria With Acute Kidney Injury After a Single Dose of Acetazolamide: A Case Study of a Rare Side Effect.单次服用乙酰唑胺后出现出血性无尿伴急性肾损伤:罕见副作用的病例研究
Cureus. 2020 Aug 29;12(8):e10107. doi: 10.7759/cureus.10107.
6
Anuric Acute Kidney Injury Induced by Acute Mountain Sickness Prophylaxis With Acetazolamide.乙酰唑胺预防急性高原病所致无尿性急性肾损伤
J Investig Med High Impact Case Rep. 2014 Apr 9;2(2):2324709614530559. doi: 10.1177/2324709614530559.
7
Chronic open-angle glaucoma. Review for primary care physicians.慢性开角型青光眼。基层医疗医生的综述
Can Fam Physician. 2005 Sep;51(9):1229-37.
8
Acetazolamide and symptomatic metabolic acidosis in mild renal failure.乙酰唑胺与轻度肾衰竭中的症状性代谢性酸中毒
Br Med J (Clin Res Ed). 1981 Dec 5;283(6305):1527-8. doi: 10.1136/bmj.283.6305.1527.
South Med J. 1975 Apr;68(4):504-6. doi: 10.1097/00007611-197504000-00026.
4
The incidence, importance, and prophylaxis of acute mountain sickness.急性高山病的发病率、重要性及预防
Lancet. 1976 Nov 27;2(7996):1149-55. doi: 10.1016/s0140-6736(76)91677-9.