Nelson W E, Doherty C C, Douglas J F, McGeown M G, Delargy H, Temple D J
Proc Eur Dial Transplant Assoc. 1983;19:544-51.
Plasma prednisolone concentrations were measured in 26 renal transplant (RT) patients and five control subjects. A linear relationship was found between prednisolone dosage in mg/kg and area under the plasma concentration time curve in seven stable RT patients (r = 0.98) and in all subjects (n = 19) with estimated prednisolone clearance rates (CLp) between 0.075 and 0.11 L/kg/hr (r = 0.96). The greatest deviation from this occurred in five patients having reduced CLp with prolonged prednisolone half life (t1/2p) and in one having increased CLp while taking phenytoin. Three of the five with reduced clearance had steroid induced diabetes and one a Cushingoid appearance. There was some correlation between peak plasma prednisolone and dosage (r = 0.77) in all subjects, but none between creatinine clearance and t1/2p or CLp.
对26例肾移植（RT）患者和5名对照受试者的血浆泼尼松龙浓度进行了测量。在7例病情稳定的RT患者中，发现泼尼松龙剂量（mg/kg）与血浆浓度-时间曲线下面积之间存在线性关系（r = 0.98）；在所有估计泼尼松龙清除率（CLp）介于0.075至0.11 L/kg/hr之间的受试者（n = 19）中也存在这种关系（r = 0.96）。这种关系的最大偏差出现在5例CLp降低且泼尼松龙半衰期（t1/2p）延长的患者中，以及1例服用苯妥英钠时CLp增加的患者中。5例清除率降低的患者中有3例患有类固醇诱导的糖尿病，1例有库欣样外观。在所有受试者中，血浆泼尼松龙峰值与剂量之间存在一定相关性（r = 0.77），但肌酐清除率与t1/2p或CLp之间无相关性。
