Haibach H, Rosenholtz M J
Am J Clin Pathol. 1983 Aug;80(2):252-5. doi: 10.1093/ajcp/80.2.252.
The case of an 11-year-old boy with prepubertal gynecomastia is presented. Endocrine workup, including sex steroid and pituitary hormone concentrations, as well as chromosome analysis, was normal. Microscopy of the mastectomy specimen demonstrated, in addition to ductal proliferation and fibrosis, formation of lobules and acini, simulating female breast tissue. The authors report the fourth case with this histologic feature. Review of the literature identified 41 cases of prepubertal gynecomastia; associated or underlying conditions were: adrenal adenoma or carcinoma in nine cases, testicular tumor in two, 11-beta-hydroxylase deficiency in four, familial gynecomastia in two, tuberous sclerosis in two, and, in part overlapping, sexual precocity in four. Gynecomastia usually regressed after tumor removal or cortisol replacement therapy. Histologic examination of breast tissue was performed in 18 cases. Lobule and acinus formation was described in only three.
本文报告了一例11岁青春期前男性乳腺增生症患者。包括性类固醇和垂体激素浓度在内的内分泌检查以及染色体分析均正常。乳房切除术标本的显微镜检查显示，除导管增生和纤维化外，还形成了小叶和腺泡，类似女性乳腺组织。作者报告了第四例具有这种组织学特征的病例。文献回顾发现41例青春期前男性乳腺增生症；相关或潜在疾病包括：9例肾上腺腺瘤或癌、2例睾丸肿瘤、4例11-β-羟化酶缺乏症、2例家族性男性乳腺增生症、2例结节性硬化症，以及部分重叠的4例性早熟。男性乳腺增生症通常在肿瘤切除或皮质醇替代治疗后消退。18例患者进行了乳腺组织的组织学检查。仅3例描述有小叶和腺泡形成。
