Varga S V, Sinitsyn P V
Probl Endokrinol (Mosk). 1978 Jan-Feb;24(1):107-11.
The influence of testosterone and antiandrogen 4-nitro-3-trifluoromethylisobutyranilide (4N3TFMIBA) on the content and biosynthesis of nucleic acids and the protein in the ventral prostate and the seminal vesicles of Wistar rats was studied under experimental conditions. As revealed, with the simultaneous administration of the androgen and its antagonist there was a fall in the organs under study of the RNA and protein content and a reduction of incorporation of labeled precursors into the DNA, RNA, and protein. Similar changes were seen after castration. A conclusion was drawn that the capacity to block the stimulating influence of testosterone on the nucleic acid and protein biosynthesis underlay "castration" effects of antiandrogen 4N3TFMIBA, this causing atrophy of the accessory genital apparatus.
在实验条件下，研究了睾酮和抗雄激素4-硝基-3-三氟甲基异丁酰苯胺（4N3TFMIBA）对Wistar大鼠腹侧前列腺和精囊内核酸及蛋白质含量与生物合成的影响。结果显示，同时给予雄激素及其拮抗剂时，所研究器官中的RNA和蛋白质含量下降，标记前体掺入DNA、RNA和蛋白质的量减少。去势后也观察到类似变化。得出的结论是，抗雄激素4N3TFMIBA的“去势”作用在于其阻断睾酮对核酸和蛋白质生物合成的刺激影响的能力，这导致附属生殖器官萎缩。
