对接受放疗的T3、NX、MO期膀胱癌患者采用阿霉素（多柔比星）和5-氟尿嘧啶进行辅助化疗。

Adjuvant chemotherapy with doxorubicin (Adriamycin) and 5-fluorouracil in T3, NX, MO bladder cancer treated with radiotherapy.

作者信息

Richards B, Bastable J R, Freedman L, Glashan R W, Harris G, Newling D W, Robinson M R, Smith P H

出版信息

Br J Urol. 1983 Aug;55(4):386-91. doi: 10.1111/j.1464-410x.1983.tb03328.x.

DOI:10.1111/j.1464-410x.1983.tb03328.x

Abstract

Radical radiotherapy alone has been compared with radical radiotherapy followed by chemotherapy using doxorubicin (Adriamycin) and 5-fluorouracil in a randomised prospective study on 129 patients presenting with T3, NX, MO transitional cell carcinoma of the bladder. One hundred and ten patients were evaluable with a minimum follow-up of 2 years. The addition of this form of chemotherapy did not appear to influence the survival rate or the proportion of patients free from tumour. It cannot be recommended for routine use in the primary treatment of infiltrating bladder cancer.

摘要

在一项针对129例T3、NX、M0期膀胱移行细胞癌患者的随机前瞻性研究中，对单纯根治性放疗与根治性放疗后使用阿霉素（多柔比星）和5-氟尿嘧啶进行化疗的效果进行了比较。110例患者可进行评估，最短随访时间为2年。这种化疗方式的加入似乎并未影响生存率或无瘤患者的比例。不推荐将其常规用于浸润性膀胱癌的初始治疗。