Johnston G D, Nicholls D P, Leahey W J, Finch M B
Clin Sci (Lond). 1983 Oct;65(4):359-63. doi: 10.1042/cs0650359.
To examine the importance of angiotensin II formation in the production of frusemide's acute peripheral venous and arterial responses, the effect of pretreatment with captopril was studied. Captopril abolished the acute increases in venous capacitance and blood pressure and attenuated the increases in forearm vascular resistance produced by intravenous frusemide. The study provides evidence that angiotensin II formation performs an essential role in the production of the acute vascular effects of frusemide in man.
为研究血管紧张素II生成在速尿急性外周静脉和动脉反应产生中的重要性，研究了卡托普利预处理的效果。卡托普利消除了静脉容量和血压的急性升高，并减弱了静脉注射速尿引起的前臂血管阻力增加。该研究提供了证据，表明血管紧张素II生成在速尿对人体的急性血管效应产生中起重要作用。
