Percival-Smith R, Bartlett K H, Chow A W
Contraception. 1983 May;27(5):497-504. doi: 10.1016/0010-7824(83)90046-x.
The prevalence rate of vaginal colonization with E. coli was studied prospectively among 495 healthy premenopausal women, and factors associated with vaginal carriage of E. coli were examined. Vaginal colonization with E. coli was found in 12% of women, and was significantly correlated with phase of the menstrual cycle (p less than 0.05), prior use of antibiotics (p less than 0.05), current genital complaints (p less than 0.05), history of previous urinary tract infection (p less than 0.001), and use of diaphragm or cervical cap for contraception (p less than 0.005). The high prevalence rate among diaphragm or cervical cap users remained significant when other confounding factors were kept constant (p less than 0.05). This observation may explain the association of diaphragm use and urinary tract infection demonstrated in previous epidemiologic studies and confirmed in the present study (p less than 0.05).
对495名健康的绝经前女性进行了前瞻性研究，以探讨大肠杆菌阴道定植的患病率，并检查了与大肠杆菌阴道携带相关的因素。12%的女性存在大肠杆菌阴道定植，且与月经周期阶段（p<0.05）、既往使用抗生素情况（p<0.05）、当前生殖器不适（p<0.05）、既往尿路感染史（p<0.001）以及使用隔膜或宫颈帽避孕（p<0.005）显著相关。当其他混杂因素保持恒定时，隔膜或宫颈帽使用者中的高患病率仍然显著（p<0.05）。这一观察结果可能解释了先前流行病学研究中所证明并在本研究中得到证实的隔膜使用与尿路感染之间的关联（p<0.05）。
