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链激酶和对氨甲苯酰纤溶酶原链激酶复合物。它们对人类志愿者止血功能的作用。

Streptokinase and anisoylated streptokinase plasminogen complex. Their action on haemostasis in human volunteers.

作者信息

Staniforth D H, Smith R A, Hibbs M

出版信息

Eur J Clin Pharmacol. 1983;24(6):751-6. doi: 10.1007/BF00607082.

DOI:10.1007/BF00607082
PMID:6350023
Abstract

A new fibrinolytic agent, BRL 26921, a member of the novel class of thrombolytic agents; the acyl enzymes, has been compared with streptokinase. It has been shown that this new agent, which can bind to fibrin before releasing activator, does not result in clinically significant destruction of the haemostatic system when compared to an equivalent dose of streptokinase.

摘要

一种新型纤溶药物BRL 26921,属于新型溶栓药物——酰基酶类,已与链激酶进行了比较。结果表明,这种新型药物在释放激活剂之前能够与纤维蛋白结合,与等量的链激酶相比,不会导致止血系统发生具有临床意义的破坏。

相似文献

1
Streptokinase and anisoylated streptokinase plasminogen complex. Their action on haemostasis in human volunteers.链激酶和对氨甲苯酰纤溶酶原链激酶复合物。它们对人类志愿者止血功能的作用。
Eur J Clin Pharmacol. 1983;24(6):751-6. doi: 10.1007/BF00607082.
2
Preclinical pharmacological evaluation of anisoylated plasminogen streptokinase activator complex.茴香酰化纤溶酶原链激酶激活剂复合物的临床前药理学评价
Drugs. 1987;33 Suppl 3:33-50. doi: 10.2165/00003495-198700333-00005.
3
Evidence for a sustained fibrinolytic response to anisoylated plasminogen streptokinase activator complex in vitro.体外对茴香酰化纤溶酶原链激酶激活剂复合物持续纤溶反应的证据。
Drugs. 1987;33 Suppl 3:83-7. doi: 10.2165/00003495-198700333-00012.
4
On the fibrinolytic and thrombolytic properties of active-site p-anisoylated streptokinase-plasminogen complex (BRL 26921).活性位点对茴香酰化链激酶-纤溶酶原复合物(BRL 26921)的纤溶和溶栓特性研究
Thromb Res. 1981 Nov 15;24(4):347-58. doi: 10.1016/0049-3848(81)90008-6.
5
Acylated plasminogen-streptokinase activator complex: a new approach to thrombolytic therapy.酰化纤溶酶原-链激酶激活剂复合物:溶栓治疗的新方法。
Pharmacotherapy. 1990;10(2):115-26.
6
A comparison of acylated streptokinase-plasminogen complex and streptokinase in healthy volunteers.健康志愿者中酰化链激酶-纤溶酶原复合物与链激酶的比较。
Thromb Haemost. 1982 Apr 30;47(2):132-5.
7
Development and evaluation of anisoylated plasminogen streptokinase activator complex (APSAC) as a second generation thrombolytic agent.第二代溶栓剂茴香酰化纤溶酶原链激酶激活剂复合物(APSAC)的研发与评估。
J Am Coll Cardiol. 1987 Nov;10(5 Suppl B):22B-27B. doi: 10.1016/s0735-1097(87)80424-2.
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Evaluation of the efficacy and safety of anisoylated plasminogen streptokinase activator complex in early myocardial infarction. Preliminary results.茴香酰化纤溶酶原链激酶激活剂复合物在急性心肌梗死中的疗效与安全性评估:初步结果
Drugs. 1987;33 Suppl 3:186-8. doi: 10.2165/00003495-198700333-00032.
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Consequences of antibody binding in vitro on the pharmacological properties of anisoylated plasminogen streptokinase activator complex.体外抗体结合对茴香酰化纤溶酶原链激酶激活剂复合物药理特性的影响。
Drugs. 1987;33 Suppl 3:64-8. doi: 10.2165/00003495-198700333-00008.
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[Anistreplase. Pharmacology and biological data].[茴酰化纤溶酶原链激酶激活剂复合物。药理学和生物学数据]
Arch Mal Coeur Vaiss. 1990 Feb;83 Spec No 1:15-20.

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2
Systemic effects of anisoylated plasminogen streptokinase activator complex and streptokinase therapy in acute myocardial infarction. Coagulation aspects of the Dutch Invasive Reperfusion Study.茴香酰化纤溶酶原链激酶激活剂复合物和链激酶治疗急性心肌梗死的全身效应。荷兰侵入性再灌注研究的凝血方面。
Drugs. 1987;33 Suppl 3:242-6. doi: 10.2165/00003495-198700333-00045.
3
Dose-ranging studies of anisoylated plasminogen streptokinase activator complex. Studies in healthy volunteers and in patients with acute myocardial infarction.

本文引用的文献

1
Fibrinolysis with acyl-enzymes: a new approach to thrombolytic therapy.酰基酶介导的纤维蛋白溶解:溶栓治疗的新方法。
Nature. 1981 Apr 9;290(5806):505-8. doi: 10.1038/290505a0.
2
Evaluation of a rapid method for the determination of plasma fibrinogen.血浆纤维蛋白原测定快速方法的评估
J Clin Pathol. 1970 Feb;23(1):43-6. doi: 10.1136/jcp.23.1.43.
3
Molecular mechanism of physiological fibrinolysis.生理性纤维蛋白溶解的分子机制。
Drugs. 1987;33 Suppl 3:124-32. doi: 10.2165/00003495-198700333-00020.
4
Anisoylated plasminogen streptokinase activator complex (APSAC). A review of its mechanism of action, clinical pharmacology and therapeutic use in acute myocardial infarction.茴香酰化纤溶酶原链激酶激活剂复合物(APSAC)。对其作用机制、临床药理学及在急性心肌梗死中的治疗应用的综述。
Drugs. 1987 Jul;34(1):25-49. doi: 10.2165/00003495-198734010-00002.
Nature. 1978 Apr 6;272(5653):549-50. doi: 10.1038/272549a0.
4
Methods for determination of plasmin, antiplasmin and plasminogen by means of substrate S-2251.
Haemostasis. 1978;7(2-3):138-45. doi: 10.1159/000214252.