Carter D A, Lakhani S, Whitehead S A
J Reprod Fertil. 1983 Sep;69(1):57-64. doi: 10.1530/jrf.0.0690057.
The time-course of the inhibitory effect of hyperprolactinaemia on LH secretion was delineated. Hyperprolactinaemia was induced in ovariectomized rats with injections of domperidone or ovine prolactin and circulating LH levels were measured from 1 h to 9 days after the treatment. Inhibition of LH secretion occurred within 2-4 h after treatment, and was maintained (provided that serum prolactin remained elevated) for a period of 6 days only. Thereafter LH levels increased to become insignificantly different from control levels on Day 9. A reduction in pituitary responsiveness was not associated with the acute or sub-chronic inhibition of LH secretion, although a significant fall in responsiveness was observed simultaneously with the return of serum LH levels to control values. No changes in hypothalamic LH-RH content was found. It is concluded that an impairment of pituitary function is not responsible for the inhibitory action of prolactin on LH secretion.
研究了高催乳素血症对促黄体生成素（LH）分泌抑制作用的时间进程。通过给去卵巢大鼠注射多潘立酮或羊催乳素诱导高催乳素血症，并在治疗后1小时至9天测量循环中的LH水平。治疗后2 - 4小时内出现LH分泌抑制，且仅在血清催乳素保持升高的情况下维持6天。此后，LH水平在第9天升高至与对照水平无显著差异。尽管在血清LH水平恢复到对照值的同时观察到垂体反应性显著下降，但垂体反应性降低与LH分泌的急性或亚慢性抑制无关。未发现下丘脑促性腺激素释放激素（LH - RH）含量有变化。得出的结论是，垂体功能受损并非催乳素对LH分泌抑制作用的原因。
