[Familial cutaneous leiomyomas and their association with uterine myoma. Study of a 3-generation pedigree].

A review of the classification, localization, symptoms, age of on-set and incidence according to sex of the cutaneous leiomyomas in done. Besides the hereditary aspect and the association of extracutaneous lesions, especially the uterus, are considered. We present the case two sisters affected by multiple cutaneous leiomyoma in association with uterine leiomyoma. Both, members of a family in which the father and 4 of the 8 offsprings present multiple cutaneous leiomyoma, and the daughter of one of the female members (third generation) is also affected of leiomyoma of the uterus. We conclude that the presentation of the leiomyoma in this family is more than a mere coincidence and that there must be some hereditary mechanism, which is interpreted as dominant and the penetrance of the autosomal dominant gene would be about 56%.