Meyer G, Nicoli J
Med Trop (Mars). 1983 May-Jun;43(3):217-25.
The carcinogenic transformation depends on the presence of particular genes, the oncogenes, which are, as a matter of fact, normal cellular genes. The oncogenic retro-viruses are mosaic genomes, transducing oncogenes in the infected cells. These genes are expressed: the product has an activity of protein kinase. The expression is increased in the transformed cells, because the oncogenes are either linked to strong viral promoters in the oncogenic viruses, or translocated in the vicinity of immunoglobulin genes in the case of Burkitt lymphoma. Moreover, there is some modifications (punctual mutations or deletions) of the primary sequence of the protein.
致癌转化取决于特定基因即癌基因的存在，而这些基因实际上是正常的细胞基因。致癌逆转录病毒是镶嵌基因组，可在受感染细胞中转导癌基因。这些基因得以表达：其产物具有蛋白激酶活性。在转化细胞中表达增加，这是因为癌基因要么与致癌病毒中的强病毒启动子相连，要么在伯基特淋巴瘤的情况下易位至免疫球蛋白基因附近。此外，蛋白质的一级序列存在一些修饰（点突变或缺失）。
