结缔组织疾病的比较病理学
Comparative pathology of connective tissue diseases.
作者信息
Leader R W, Hegreberg G A, Padgett G A, Wagner B M
出版信息
Monogr Pathol. 1983;24:150-62.
Selected examples of animal models for human connective tissue diseases are reviewed, with emphasis on those which can be verified by genetic, immunologic, and biochemical studies. Desnick et al. have stated that the study of animal models in inborn errors of metabolism will "have a dramatic impact on the future development and evaluation of effective therapies for a variety of human enzyme diseases." It is hoped that these discussions, including comments on the importance of animal models for specific human diseases of the connective tissue, will yield significant benefits in human health.
本文综述了人类结缔组织疾病动物模型的一些选定实例，重点关注那些可通过遗传学、免疫学和生物化学研究加以验证的模型。德斯尼克等人指出，对先天性代谢缺陷动物模型的研究“将对多种人类酶病有效治疗方法的未来发展和评估产生巨大影响”。希望这些讨论，包括对结缔组织特定人类疾病动物模型重要性的评论，能给人类健康带来显著益处。
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