Kaar M L, Kaapa P, Viinikka L, Ylikorkala O
Prostaglandins Leukot Med. 1983 Jul;11(3):339-44. doi: 10.1016/0262-1746(83)90045-8.
Plasma concentrations of a stable metabolite of prostacyclin, 6-keto-prostaglandin Fla (6-keto-PGF1a), and the ability of platelets to generate thromboxane B2 (TxB2), a metabolite of thromboxane A2, during spontaneous clotting of the blood were measured in 40 diabetic children and 16 healthy controls. The diabetics' platelets generated TxB2 to a lesser extent than those of controls, whereas no difference was seen in plasma 6-keto-PGF1a concentration. The balance and duration of diabetes were not related to TxB2 or 6-Keto-PGF1a. The results do not support the theory that an absolute or relative prostacyclin deficiency could trigger the onset of diabetic vascular complications.
在40名糖尿病儿童和16名健康对照者中，测量了血液自然凝固过程中前列环素的稳定代谢产物6-酮-前列腺素F1α（6-keto-PGF1α）的血浆浓度，以及血小板生成血栓素A2的代谢产物血栓素B2（TxB2）的能力。糖尿病患者的血小板生成TxB2的程度低于对照组，而血浆6-keto-PGF1α浓度未见差异。糖尿病的病程和病情严重程度与TxB2或6-酮-前列腺素F1α无关。这些结果不支持前列环素绝对或相对缺乏会引发糖尿病血管并发症的理论。
