Stoltz J F
Thromb Res. 1983;Suppl 5:73-82.
The electrochemical phenomena related to the negative charge of blood cells have provided a means of defining the importance of these parameters in vascular thrombosis. In parallel with these works, measurements of transmembrane potential have revealed that the vessel wall also carries negative charges and thus takes part in the repulsion of blood cells and prevents them from being adhesive on the intima. These charges come from various origins (ion or protein adsorption, active transfer through the vascular wall, ionized groups...). Vascular potential can be approached by means of various techniques: transmembrane potential (electro-osmosis), circulation potential (in vitro and in vivo). On the basis of published results and his own personal research, the author compares the different values that have been obtained. Consequently, it has been observed that the transmembrane charge measurements that are accessible using electro-osmosis techniques and streaming potential do reflect some discordances according to the methods used. The importance of these parameters and the part they play in thrombosis phenomena is discussed.
与血细胞负电荷相关的电化学现象为确定这些参数在血管血栓形成中的重要性提供了一种方法。与这些研究并行的是，跨膜电位测量表明血管壁也带有负电荷，因此参与了对血细胞的排斥作用，并防止它们黏附在内膜上。这些电荷有多种来源（离子或蛋白质吸附、通过血管壁的主动转运、离子化基团等）。血管电位可以通过各种技术来测定：跨膜电位（电渗）、循环电位（体外和体内）。基于已发表的结果和他自己的个人研究，作者比较了所获得的不同数值。因此，已经观察到使用电渗技术和流动电位可进行的跨膜电荷测量根据所使用的方法确实反映出一些差异。本文讨论了这些参数的重要性及其在血栓形成现象中所起的作用。
