Moulin G, Martel J L, Guillot J F, Libmann M
Ann Rech Vet. 1983;14(2):121-7.
Enteropathogenic antibiotic resistant E. coli (K99+, ST+) were selected and numbered in the faeces of cows and their newborn calves from a farm where outbreaks of neo-natal diarrhoea occurred occasionally. K99+ E. coli were resistant to nalidixic acid. This resistance rarely encountered, enabled to number selectively these bacteria. In the eight affected calves, the K99+ strains were simultaneously resistant to nalidixic acid, ampicillin, streptomycin, kanamycin, chloramphenicol, tetracyclines and sulphonamides. In the cases of severe diarrhoea, these K99+ E. coli predominated in the faecal flora. Strains presenting the same characters were also isolated from the faeces of the mothers, where they were generally found in lesser numbers. When calves were prophylactically treated with gentamicin or when their mothers had been vaccinated against enteropathogenic E. coli, clinical signs of diarrhoea did not appear or were mild, but carriage of K99+ E. coli persisted. These first results contribute to a better understanding of the epidemiology of neonatal colibacillosis in calves.
从一个偶尔爆发新生犊牛腹泻的农场中，选择并编号了来自母牛及其新生犊牛粪便中的致病性抗抗生素大肠杆菌（K99 +，ST +）。K99 +大肠杆菌对萘啶酸耐药。这种耐药性很少见，使得能够选择性地对这些细菌进行计数。在八头受影响的犊牛中，K99 +菌株同时对萘啶酸、氨苄青霉素、链霉素、卡那霉素、氯霉素、四环素和磺胺类药物耐药。在严重腹泻的情况下，这些K99 +大肠杆菌在粪便菌群中占主导地位。从母牛的粪便中也分离出具有相同特征的菌株，但其数量通常较少。当犊牛用庆大霉素进行预防性治疗或其母亲接种了抗致病性大肠杆菌疫苗时，腹泻的临床症状未出现或很轻微，但K99 +大肠杆菌的携带持续存在。这些初步结果有助于更好地了解犊牛新生大肠杆菌病的流行病学。
