氯贝丁酯对小鼠P 1798（sc）淋巴瘤生长动力学的影响。
Effect of clofibrate on the growth-kinetics of the murine P 1798(sc) lymphoma.
作者信息
Ubeira F M, Seoane R, Puentes E, Faro J, Regueiro B J
出版信息
Br J Cancer. 1983 Sep;48(3):417-21. doi: 10.1038/bjc.1983.207.
Clofibrate (CPIB) is a drug applied as an antilipidaemic agent in mammals. In this work we have tested its efficacy in vivo on the growth kinetics of P 1798(sc) lymphoma transplanted to recipient (BALB/c x AKR)F1 mice. Our results show a facilitation of the tumour growth rate in treated recipients. This fact may be related to an effect of the agent on the recipient which produces a decrease in the immune response as was confirmed on testing CPIB on thymus-dependent antigens in haemolytic plaque assays.
氯贝丁酯（CPIB）是一种在哺乳动物中用作抗血脂药的药物。在这项工作中，我们测试了其对移植到受体（BALB/c×AKR）F1小鼠体内的P1798（sc）淋巴瘤生长动力学的体内疗效。我们的结果显示，治疗后的受体肿瘤生长速率加快。这一事实可能与该药物对受体的作用有关，这种作用会导致免疫反应降低，这在溶血空斑试验中对胸腺依赖性抗原测试氯贝丁酯时得到了证实。
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