Martucci N, Manna V, Mattesi P, Troiani G, Manzoni G C, Lanfranchi M, Bono G, Micieli G
Cephalalgia. 1983 Aug;3 Suppl 1:151-5. doi: 10.1177/03331024830030S124.
In this multicentric random double-blind study versus placebo, the therapeutic activity of timed-release dihydroergotamine preparation 10 mg/per os/day has been tested in 90 patients affected by common migraine. The drug presented a prophylactic effect on recurrent headache, mainly on night and awakening migraine. A low incidence of side-effects with no weight changes or other effects on physiologic events was registered.
在这项针对安慰剂的多中心随机双盲研究中，对90名普通偏头痛患者测试了10毫克/口服/天的缓释二氢麦角胺制剂的治疗活性。该药物对复发性头痛有预防作用，主要是对夜间和晨起偏头痛。记录到副作用发生率较低，且对体重无变化或对生理事件无其他影响。
