Lameijer L D, Houtzagers J J, Voermans L A
Eur Heart J. 1983 Jul;4 Suppl D:53-6. doi: 10.1093/eurheartj/4.suppl_d.53.
In a randomized controlled, double-blind clinical trial with 45 patients with moderate hypertension atenolol 100 mg and penbutolol 40 mg were equally effective in lowering the blood pressure. During the 6 weeks of treatment there was no change in body weight and serious side-effects were not observed, but bradycardia occurred more frequently with atenolol than with penbutolol. Withdrawal of medication during the final week of the study did not cause any adverse reaction.
在一项针对45名中度高血压患者的随机对照双盲临床试验中，阿替洛尔100毫克和喷布洛尔40毫克在降低血压方面效果相当。在为期6周的治疗期间，体重没有变化，也未观察到严重的副作用，但阿替洛尔引起心动过缓的频率高于喷布洛尔。在研究的最后一周停药未引起任何不良反应。
