Hansson B G, Dymling J F, Manhem P, Hökfelt B
Eur Heart J. 1983 Jul;4 Suppl D:57-60. doi: 10.1093/eurheartj/4.suppl_d.57.
The effects of penbutolol 20-30 mg twice daily and of metoprolol 50-150 mg three times daily were studied in five and nine patients, respectively, with moderate hypertension. Both drugs significantly reduced blood pressure and pulse rate under basal conditions and in connection with exercise. Plasma catecholamine levels were not altered in supine or upright position, neither during penbutolol nor during metoprolol treatment. Following work there was an enhanced response in both plasma noradrenaline and adrenaline during penbutolol but only in plasma noradrenaline during metoprolol treatment. Both drugs effectively reduced basal plasma renin activity but only penbutolol abolished the renin response to work. Penbutolol significantly reduced urinary aldosterone excretion whereas metoprolol caused no significant changes. Neither penbutolol nor metoprolol affected maximal working capacity.
分别对5例和9例中度高血压患者进行研究，观察每日两次服用20 - 30毫克喷布洛尔以及每日三次服用50 - 150毫克美托洛尔的效果。两种药物在基础状态下以及运动时均能显著降低血压和脉搏率。在喷布洛尔和美托洛尔治疗期间，仰卧位或直立位时血浆儿茶酚胺水平均未改变。运动后，喷布洛尔治疗期间血浆去甲肾上腺素和肾上腺素反应增强，而美托洛尔治疗期间仅血浆去甲肾上腺素反应增强。两种药物均有效降低基础血浆肾素活性，但只有喷布洛尔能消除运动引起的肾素反应。喷布洛尔显著降低尿醛固酮排泄，而美托洛尔未引起显著变化。喷布洛尔和美托洛尔均不影响最大工作能力。
