Izumi H, Ho S C, Michelakis A M, Aoki T
Eur J Pharmacol. 1983 Jul 22;91(2-3):295-9. doi: 10.1016/0014-2999(83)90482-x.
The effects of subcutaneous injection of compound 48/80 and histamine on the water intake, plasma renin activity (PRA) and plasma histamine levels were investigated in the rat. The results suggest that compound 48/80 and histamine stimulate water intake by different mechanisms. The compound 48/80-induced water intake seems to be mainly mediated by stimulation of the renin-angiotensin system. On the other hand, the histamine-induced water intake seems to be directly mediated by its action in the brain.
在大鼠中研究了皮下注射化合物48/80和组胺对水摄入量、血浆肾素活性（PRA）和血浆组胺水平的影响。结果表明，化合物48/80和组胺通过不同机制刺激水摄入。化合物48/80诱导的水摄入似乎主要由肾素-血管紧张素系统的刺激介导。另一方面，组胺诱导的水摄入似乎直接由其在脑中的作用介导。
