Geissler E N, Russell E S
Exp Hematol. 1983 Jul;11(6):452-60.
Mice carrying two mutant W alleles usually have severe macrocytic anemias which result from deficiencies of hematopoietic stem cells (CFUs) (1). Anemic W39/W39 and W41/W41 homozygotes (2) have deficiencies in the numbers of femoral stem cells which correspond to the severities of their anemias. The non-anemic W44/W44 homozygote (2) has a few stem cells as the W41/W41 mouse. Nevertheless, bone marrow implants from W44/W44 donors cure the anemias of W/Wv recipients while implants from anemic W39/W39 and W41/W41 donors do not. The peripheral hematologic differences between W41/W41 and W44/W44 homozygotes probably arise from qualitative differences intrinsic to their stem cells rather than from extrinsic hematopoietic factors. The hematopoietic environments of all three W homozygotes are relatively normal in that they support normal erythropoiesis when injected with congenic +/+ marrow. Even non-anemic W44/W44 recipients are repopulated with +/+ donor red cells, indicating that W44/W44 stem cells are at a disadvantage when competing with normal counterparts.
携带两个突变W等位基因的小鼠通常患有严重的巨幼细胞贫血，这是由造血干细胞（CFUs）缺陷引起的（1）。贫血的W39/W39和W41/W41纯合子（2）的股骨干细胞数量存在缺陷，这与它们贫血的严重程度相对应。非贫血的W44/W44纯合子（2）的干细胞数量与W41/W41小鼠一样少。然而，来自W44/W44供体的骨髓移植能治愈W/Wv受体的贫血，而来自贫血的W39/W39和W41/W41供体的移植则不能。W41/W41和W44/W44纯合子之间的外周血液学差异可能源于其干细胞固有的质量差异，而非外在的造血因子。所有三种W纯合子的造血环境相对正常，因为当注入同基因的+/+骨髓时，它们支持正常的红细胞生成。即使是非贫血的W44/W44受体也会被+/+供体红细胞重新填充，这表明W44/W44干细胞在与正常对应细胞竞争时处于劣势。
