Astvatsaturian M Z, Mironov A S, Sukhodolets V V
Genetika. 1983 Jul;19(7):1070-4.
A number of rifampicin resistance mutations which have been mapped in the region of the rpoB gene, cause an increase in the activity level of a catabolite sensitive uridine phosphorylase (udp) gene. This effect is observed in bacterial cells deficient for the active protein repressor cytR, controlling expression of the udp gene. In cytR mutant cells grown on the medium containing glucose, the level of uridine phosphorylase is further increased by a factor of 1,5 to 2 under the influence of rif-r mutations. Concomitantly, the activity of some other catabolite sensitive genes controlled by the cytR protein is also increased on the medium with glucose. The data obtained suggest that the RNA polymerase beta-subunit participates in regulation of some catabolite sensitive genes.
一些已定位在rpoB基因区域的利福平抗性突变，会导致一种对分解代谢物敏感的尿苷磷酸化酶（udp）基因的活性水平增加。在缺乏活性蛋白阻遏物cytR（其控制udp基因的表达）的细菌细胞中可观察到这种效应。在含有葡萄糖的培养基上生长的cytR突变细胞中，在利福平抗性（rif-r）突变的影响下，尿苷磷酸化酶的水平会进一步提高1.5至2倍。同时，在含有葡萄糖的培养基上，由cytR蛋白控制的其他一些对分解代谢物敏感的基因的活性也会增加。所获得的数据表明，RNA聚合酶β亚基参与了一些对分解代谢物敏感的基因的调控。
