Strandvik B, Malmborg A S, Alfredson H, Ericsson A
J Antimicrob Chemother. 1983 Jul;12 Suppl A:283-7. doi: 10.1093/jac/12.suppl_a.283.
Ceftazidime (50 mg/kg/8 h) alone or combined with tobramycin (5 mg/kg/8 h) was given to 14 patients with cystic fibrosis. Ten courses were given with ceftazidime alone and 6 courses with a combined therapy. All patients were chronically colonized with Pseudomonas aeruginosa and were hospitalized because of lower respiratory tract infections. Using an agar-well diffusion technique, the concentration of ceftazidime was determined in serum and sputum. The mean (+/- S.E.M.) peak serum concentration of ceftazidime was 142 +/- 16 mg/l during the second to third day of treatment and 114 +/- 18 mg/l on the fifth to sixth day of treatment. In the combined therapy the corresponding values were 104 +/- 20 mg/l and 74 +/- 8 mg/l, respectively. The range of the mean half life was 1.2 to 1.4 h. The maximum concentration of ceftazidime in sputum was usually obtained 1 h after the infusion, ranging from 0.7 to 9.8 mg/l. All patients improved during treatment. Non-mucoid strains of Ps. aeruginosa were eradicated in nearly half of the courses, mucoid strains less often. No side reactions were noted.
对14例囊性纤维化患者单独给予头孢他啶（50mg/kg/8小时）或联合妥布霉素（5mg/kg/8小时）治疗。单独使用头孢他啶治疗10个疗程，联合治疗6个疗程。所有患者均长期感染铜绿假单胞菌，并因下呼吸道感染住院。采用琼脂孔扩散技术测定血清和痰液中头孢他啶的浓度。治疗第二天至第三天，头孢他啶的平均（±标准误）血清峰值浓度为142±16mg/L，治疗第五天至第六天为114±18mg/L。联合治疗时相应的值分别为104±20mg/L和74±8mg/L。平均半衰期范围为1.2至1.4小时。痰液中头孢他啶的最高浓度通常在输注后1小时达到，范围为0.7至9.8mg/L。所有患者在治疗期间均有改善。近一半疗程中根除了非黏液型铜绿假单胞菌菌株，黏液型菌株较少见。未观察到副作用。
