Ridley M J, Heather C J, Ridley D S, Willoughby D A
J Pathol. 1983 Sep;141(1):41-54. doi: 10.1002/path.1711410106.
In previous studies it was found that infections with BCG or complexed BCG/anti-BCG in rat skin produced granulomas that appeared to resolve at 8 months. In this follow-up study 1 year later, it appeared that while lesions due to performed complexes had resolved, those due to BCG alone had undergone a massive reactivation. Nevertheless despite the loss of CMI the infection was restricted. The bacilli, present in enormously increased numbers, were dead; the host macrophages were large and activated. Epithelioid cells and dendritic cells were common. The granuloma was confluent, with patchy necrosis and inconspicuous polymorph infiltration. Although preformed complexes with viable bacilli formed at equivalence had produced a resolving lesion, the outcome of the natural infection was complicated by an imponderable balance of immunological responses. CMI does not appear to have been a determinant during the crucial phases of the infection.
在先前的研究中发现，大鼠皮肤接种卡介苗（BCG）或复合卡介苗/抗卡介苗会产生肉芽肿，这些肉芽肿在8个月时似乎会消退。在1年后的这项随访研究中，虽然由预先形成的复合物引起的病变已经消退，但仅由卡介苗引起的病变却发生了大规模的再激活。然而，尽管细胞介导免疫（CMI）丧失，但感染仍受到限制。杆菌数量大幅增加，但已死亡；宿主巨噬细胞体积增大且被激活。上皮样细胞和树突状细胞很常见。肉芽肿融合，有散在坏死，多形核白细胞浸润不明显。尽管与活菌在等价状态下形成的预先形成的复合物产生了可消退的病变，但自然感染的结果因免疫反应难以估量的平衡而变得复杂。在感染的关键阶段，CMI似乎并不是一个决定性因素。
