Ninomiya K, Makino S, Hasegawa Y, Yoshimoto T
Jpn J Antibiot. 1983 May;36(5):986-93.
Experimental and clinical studies of T-1982 (cefbuperazone), a new cephamycin antibiotic, were performed in the field of obstetrics and gynecology, and the following results were observed. T-1982 was determined for its in vitro activity against 180 recent clinical isolates in comparison with cefmetazole (CMZ) and cefazolin (CEZ). The activity of T-1982 was superior to that of CMZ against E. coli (101 strains) and B. fragilis (19 strains), and similar to that of CMZ and CEZ against Peptococcus (34 strains). High concentrations of T-1982 exceeding the MIC values against various bacteria were maintained for a few hours in the female genital organs and postoperative retroperitoneal exudate after intravenous drip infusion of 2 g. T-1982 was administered to a total of 6 patients in daily dose of 2 approximately 3 g for 2 approximately 10 days. The clinical results were excellent or good in 5 cases. Drug eruption was observed in 1 case. These results suggest that T-1982 is highly effective for the treatment of bacterial infections in this field.
新型头孢霉素类抗生素T - 1982（头孢布宗）在妇产科领域进行了实验和临床研究，观察到以下结果。与头孢美唑（CMZ）和头孢唑林（CEZ）相比，测定了T - 1982对180株近期临床分离菌株的体外活性。T - 1982对大肠杆菌（101株）和脆弱拟杆菌（19株）的活性优于CMZ，对消化球菌（34株）的活性与CMZ和CEZ相似。静脉滴注2g后，T - 1982在女性生殖器官和术后腹膜后渗出液中维持超过各种细菌MIC值的高浓度达数小时。共有6例患者接受T - 1982治疗，日剂量约2至3g，疗程2至10天。5例临床结果为优或良。1例出现药疹。这些结果表明，T - 1982对该领域细菌感染的治疗非常有效。
