Muratani H, Kawasaki T, Kawano Y, Abe I, Kumamoto K, Omae T
Jpn J Med. 1983 Aug;22(3):227-30. doi: 10.2169/internalmedicine1962.22.227.
In a patient with an uncomplicated pheochromocytoma, we observed high basal value of plasma renin activity (PRA), 16.2 ng/ml/h, and a remarkable elevation in PRA from 18.2 to 90.4 ng/ml/h and concomitant blood pressure reduction following a single oral administration of 25 mg of captopril. The response was same as that observed in renovascular hypertensives, and disappeared during the period of alpha-, beta-blocker administration or after the surgery. Basal PRA also returned to low normal level. The renin-angiotensin (R-A) system probably had a role in the maintenance of high blood pressure. The mechanism of the activation of the R-A system was thought to be renal vasoconstriction due to excessive circulating catecholamines.
在一名患有单纯性嗜铬细胞瘤的患者中，我们观察到血浆肾素活性（PRA）的基础值较高，为16.2 ng/ml/h，单次口服25 mg卡托普利后，PRA从18.2 ng/ml/h显著升高至90.4 ng/ml/h，同时血压降低。该反应与肾血管性高血压患者中观察到的相同，在给予α、β受体阻滞剂期间或手术后消失。基础PRA也恢复到低正常水平。肾素-血管紧张素（R-A）系统可能在维持高血压中起作用。R-A系统激活的机制被认为是由于循环中儿茶酚胺过多导致肾血管收缩。
