[Plasma-coagulating and fibrinolytic activities of fungi in the genus Aspergillus].

The exocellular plasmocoagulating and fibrinolytic activities were studied in 100 cultures of the Aspergillus genus belonging to 29 species during their submerged cultivation in three media. It has been found that 38 cultures can coagulate human plasma, 75 cultures can cause lysis of fibrin platelets, and 22 cultures are capable of dissolving standard plasma clots within 6 hours. The cultures synthesize three types of proteolytic enzymes according to the specificity toward blood proteins: (1) proteases with the predominant fibrinolytic action; (2) proteases which possess both the fibrinolytic and plasmocoagulating activities; (3) proteases manifesting only the plasmocoagulating action. A. ochraceus 19 producing individual plasmocoagulases and fibrinolytic enzymes at a high rate was isolated. The composition of the enzyme complex synthesized by the culture depended on the composition of the medium and on the cultivation conditions.