Vallera D A, Ash R C, Zanjani E D, Kersey J H, LeBien T W, Beverley P C, Neville D M, Youle R J
Science. 1983 Nov 4;222(4623):512-5. doi: 10.1126/science.6353579.
Three new reagents that react against human T cells were synthesized by covalently linking the toxin ricin to monoclonal antibodies recognizing differentiation antigens on the surface of T lymphocytes. Each of these immunotoxins selectively inhibited T-cell proliferation when the cells were incubated in the presence of lactose. Multipotent human stem cells were inhibited only at much higher concentrations. Mixtures of all three immunotoxins were more effective than any one alone. These reagents have the potential for preventing graft-versus-host disease in man.
通过将毒素蓖麻蛋白与识别T淋巴细胞表面分化抗原的单克隆抗体共价连接，合成了三种针对人类T细胞的新型试剂。当细胞在乳糖存在的情况下孵育时，这些免疫毒素中的每一种都能选择性地抑制T细胞增殖。多能人类干细胞只有在浓度高得多的情况下才会受到抑制。三种免疫毒素的混合物比任何一种单独使用都更有效。这些试剂有预防人类移植物抗宿主病的潜力。
