Esseltine D W, De Leeuw N K, Berry G R
Cancer. 1983 Nov 15;52(10):1904-10. doi: 10.1002/1097-0142(19831115)52:10<1904::aid-cncr2820521022>3.0.co;2-k.
The clinical features, therapy, and hospital course of ten consecutive patients with malignant histiocytosis (MH) are presented. The value of bone marrow aspiration for the diagnosis is discussed. The patient's performance status as described in this report by the organ dysfunction score may predict survival and response to chemotherapy. The literature on chemotherapy in this disease is reviewed. Combination chemotherapy may be the best approach to treatment, but there is little experience with single agents. There is a great need for better characterization of the malignant cell in this disorder.
本文报告了连续10例恶性组织细胞增多症（MH）患者的临床特征、治疗方法及住院过程。讨论了骨髓穿刺在诊断中的价值。本报告中用器官功能障碍评分描述的患者体能状态可能预测生存情况及对化疗的反应。本文回顾了关于该疾病化疗的文献。联合化疗可能是最佳治疗方法，但单药治疗经验较少。非常需要更好地明确这种疾病中恶性细胞的特征。
