糖尿病肾病和非糖尿病肾病中肾功能的预测因素。

Predictors of renal function in diabetic and non-diabetic renal disease.

作者信息

Feehally J, Taverner D, Burden A C, Walls J

出版信息

Clin Chim Acta. 1983 Sep 30;133(2):169-75. doi: 10.1016/0009-8981(83)90402-3.

Abstract

Forty-two patients with renal disease due to diabetic nephropathy (14 patients), tubulointerstitial disease (14 patients) and glomerular disease (14 patients) underwent measurement of glomerular filtration rate (GFR) by the 51Cr-EDTA 'one-shot' method and simultaneous serum beta 2-microglobulin, serum creatinine and creatinine clearance estimation. Serum creatinine was a significantly better predictor of GFR than serum beta 2-microglobulin in patients with diabetic nephropathy, whereas both methods were equally useful predictors of GFR in non-diabetic renal disease. Serum creatinine measurement remains the best method for detecting early reduction of GFR on a serum sample.

摘要

42例因糖尿病肾病（14例）、肾小管间质疾病（14例）和肾小球疾病（14例）导致肾病的患者，采用51Cr-EDTA“单次注射”法测定肾小球滤过率（GFR），并同时测定血清β2-微球蛋白、血清肌酐及估算肌酐清除率。在糖尿病肾病患者中，血清肌酐作为GFR的预测指标明显优于血清β2-微球蛋白，而在非糖尿病肾病中，两种方法作为GFR的预测指标同样有效。血清肌酐测定仍然是检测血清样本中GFR早期降低的最佳方法。