纯合子镰状细胞病肾小球滤过率的测定：51Cr-乙二胺四乙酸清除率、肌酐清除率、血清肌酐和β2微球蛋白的比较
Measurement of glomerular filtration rate in homozygous sickle cell disease: a comparison of 51Cr-EDTA clearance, creatinine clearance, serum creatinine and beta 2 microglobulin.
作者信息
Aparicio S A, Mojiminiyi S, Kay J D, Shepstone B J, de Ceulaer K, Serjeant G R
机构信息
Department of Nuclear Medicine, John Radcliffe Hospital, Oxford.
出版信息
J Clin Pathol. 1990 May;43(5):370-2. doi: 10.1136/jcp.43.5.370.
Glomerular filtration rates (GFR) were measured with 51Cr-EDTA in 38 patients (aged 40-75 years) with homozygous sickle cell disease and compared with serum beta 2 microglobulin concentrations in 38 patients and with creatinine clearance in 21 patients. GFR estimated with 51Cr-EDTA was closely correlated with single serum creatinine measurements and the inverse of serum beta 2 microglobulin. Creatinine clearance was also found to be correlated, but values were, on average, 32% below those obtained by the 51Cr-EDTA method, and this difference was significant. It is concluded that measurements of beta 2 microglobulin, single serum creatinine, and creatinine clearance are valuable indicators of GFR in homozygous sickle cell disease. Measurement of beta 2 microglobulin was a useful and reliable method of estimating GFR from single plasma measurements and is therefore a useful means of screening the population.
采用51铬-乙二胺四乙酸（51Cr-EDTA）对38例（年龄40 - 75岁）纯合子镰状细胞病患者进行肾小球滤过率（GFR）测定，并与38例患者的血清β2微球蛋白浓度以及21例患者的肌酐清除率进行比较。用51Cr-EDTA估算的GFR与单次血清肌酐测量值及血清β2微球蛋白的倒数密切相关。肌酐清除率也被发现具有相关性，但平均而言，其值比用51Cr-EDTA法获得的值低32%，且这种差异具有显著性。结论是，β2微球蛋白、单次血清肌酐和肌酐清除率的测量是纯合子镰状细胞病中GFR的有价值指标。β2微球蛋白的测量是一种从单次血浆测量估算GFR的有用且可靠的方法，因此是筛查人群的一种有用手段。
Zotero 插件