Walter G F
Clin Neuropathol. 1983;2(3):101-13.
Myoencephalopathies with abnormal mitochondria comprise a heterogeneous group of diseases and syndromes with a large diversity of clinical signs. Thus, their identification and classification pose many difficulties. The underlying biochemical disorders of energy metabolism evoke non-specific structural alterations of the mitochondria in skeletal muscle and brain, but also in other organs. In this paper the morphologic and biochemical background of confirmed cases is reviewed and the position of these cases within the concept of mitochondriopathy is discussed.
伴有线粒体异常的肌脑病是一组异质性疾病和综合征，临床体征多种多样。因此，对它们的识别和分类存在许多困难。能量代谢潜在的生化紊乱不仅会引起骨骼肌和大脑中线粒体的非特异性结构改变，也会影响其他器官。本文回顾了确诊病例的形态学和生化背景，并讨论了这些病例在线粒体病概念中的定位。
