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肾上腺成像剂:原理、合成、制剂与代谢。

Adrenal imaging agents: rationale, synthesis, formulation and, metabolism.

作者信息

Beierwaltes W H, Wieland D M, Yu T, Swanson D P, Mosley S T

出版信息

Semin Nucl Med. 1978 Jan;8(1):5-21. doi: 10.1016/s0001-2998(78)80004-x.

DOI:10.1016/s0001-2998(78)80004-x
PMID:635596
Abstract

In this introductory paper on radionuclide adrenal imaging, the rationale, synthesis, formulation, and metabolism of two clinically well-established and one promisinmg adrenocortical imaging agents are reviewed. Their present clinical utility is reviewed in a separate presentation in this issue. Progress to date in developing a positive imaging agent of the adrenal medulla and tumors of chromaffin tissue will be given brief consideration because there is, as yet, no clinically successful radiolabeled adrenal medulla imaging agent.

摘要

在这篇关于放射性核素肾上腺成像的介绍性论文中,我们回顾了两种临床应用成熟和一种有前景的肾上腺皮质成像剂的原理、合成、配方及代谢情况。它们目前的临床应用将在本期另一篇文章中进行回顾。由于目前尚无临床上成功的放射性标记肾上腺髓质成像剂,因此将简要介绍肾上腺髓质及嗜铬组织肿瘤阳性成像剂的研究进展。

相似文献

1
Adrenal imaging agents: rationale, synthesis, formulation and, metabolism.肾上腺成像剂:原理、合成、制剂与代谢。
Semin Nucl Med. 1978 Jan;8(1):5-21. doi: 10.1016/s0001-2998(78)80004-x.
2
Radiation dosimetry of adrenal imaging agents 19-iodocholesterol and 6-iodomethylnorcholesterol.肾上腺显像剂19-碘胆固醇和6-碘甲基去甲胆固醇的辐射剂量学
Int J Appl Radiat Isot. 1978 May;29(4-5):277-9. doi: 10.1016/0020-708x(78)90055-8.
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Radionuclide imaging of the adrenal glands.
Clin Nucl Med. 1978 Feb;3(2):71-6. doi: 10.1097/00003072-197802000-00014.
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3-(125I) Iodo-5-cholestene: rationale for its development as a potential adrenal scanning agent.3 -(125I)碘 - 5 - 胆甾烯:将其开发为潜在肾上腺扫描剂的理论依据。
Acta Pharm Suec. 1981;18(4):227-32.
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[Comparison of a new adrenal scanning agent, 6-methyl-75Se-selenomethyl-19-norcholest-5 (10)-en-3 beta-ol (75Se-Scintadren) and 6 beta-iodomethyl-19-norcholest-5 (10)-en-3 beta-ol (131I-Adosterol) (author's transl)].
Kaku Igaku. 1979 Apr;16(2):183-9.
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[Clinical values of adrenal scintigraphy by I-6-beta-iodomethyl-19-norcholesterol (123I-NCL) (author's transl)].
Kaku Igaku. 1982 Mar;19(2):245-53.
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Imaging the adrenal glands with radiolabeled inhibitors of enzymes: concise communication.使用放射性标记的酶抑制剂对肾上腺进行成像:简要通讯
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A comparison of 19-iodocholesterol-131I with 6beta-iodomethyl-19-norcholest-5(10)-en-3beta-ol-131I as an adrenal-scanning agent.19-碘胆固醇-131I与6β-碘甲基-19-去甲胆甾-5(10)-烯-3β-醇-131I作为肾上腺扫描剂的比较。
Chem Pharm Bull (Tokyo). 1976 Oct;24(10):2322-6. doi: 10.1248/cpb.24.2322.
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Adrenal scanning and uptake with 131I-6beta-iodomethyl-nor-cholesterol.
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Uptake of 131I-19-cholesterol by normal and spontaneously hyperfunctioning canine adrenals.正常和自发性功能亢进犬肾上腺对131I-19-胆固醇的摄取
Eur J Nucl Med. 1979 Feb 1;4(1):61-67. doi: 10.1007/BF00257572.

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