[1-year monitoring of the course of chronic renal insufficiency induced by subtotal nephrectomy in rats. Pharmacokinetic value].

A subtotal nephrectomy is realized on 200 rats Wistar IOPS, producing a chronical renal failure (CRF). Evolution is studied during 12 months and compared to 100 normal rats of the same age. Biochemical criteria show an increased blood urea and creatinemia with a diminution of creatinin clearance and an appearance of important proteinuria. Morphological results show as soon as the third month, irreversible tubulo-interstitial lesions; afterwards glomerular lesions appear and become more and more visible and are accompagnied by membranous depots; then, a pan-nephritis is noted at the 10th month. These observations allow to class animals into three groups according to the CRF degree: low, medium or severe. As soon as the fifth month, all surviving animals present a medium CRF generally, or a severe CRF. Our work allows to create homogeneous lots used in pharmacokinetic applications.