Stoykova S, Casanova P, Luccioni F, Lanza M
Pathol Biol (Paris). 1983 Sep;31(7):569-76.
A subtotal nephrectomy is realized on 200 rats Wistar IOPS, producing a chronical renal failure (CRF). Evolution is studied during 12 months and compared to 100 normal rats of the same age. Biochemical criteria show an increased blood urea and creatinemia with a diminution of creatinin clearance and an appearance of important proteinuria. Morphological results show as soon as the third month, irreversible tubulo-interstitial lesions; afterwards glomerular lesions appear and become more and more visible and are accompagnied by membranous depots; then, a pan-nephritis is noted at the 10th month. These observations allow to class animals into three groups according to the CRF degree: low, medium or severe. As soon as the fifth month, all surviving animals present a medium CRF generally, or a severe CRF. Our work allows to create homogeneous lots used in pharmacokinetic applications.
对200只Wistar IOPS大鼠实施次全肾切除术，导致慢性肾衰竭（CRF）。研究其12个月内的病情发展，并与100只同龄正常大鼠进行比较。生化指标显示血尿素和肌酐血症增加，肌酐清除率降低，并出现大量蛋白尿。形态学结果显示，在第三个月时就出现了不可逆的肾小管间质病变；随后出现肾小球病变，且越来越明显，并伴有膜性沉积物；然后，在第十个月时出现全肾炎。这些观察结果使我们能够根据CRF程度将动物分为三组：轻度、中度或重度。到第五个月时，所有存活的动物一般都呈现中度CRF，或重度CRF。我们的工作有助于创建用于药代动力学应用的同质批次。
