Mizoi Y, Tatsuno Y, Adachi J, Kogame M, Fukunaga T, Fujiwara S, Hishida S, Ijiri I
Pharmacol Biochem Behav. 1983;18 Suppl 1:127-33. doi: 10.1016/0091-3057(83)90159-4.
Normal Japanese subjects were divided into two groups, i.e., one with both low and high Km isozymes of aldehyde dehydrogenase for acetaldehyde, and the other deficient in the low Km isozyme. After intake of 0.4 g/kg alcohol, the deficient subjects showed high level of blood acetaldehyde, facial flushing and the other dysphoric symptoms, including increase of pulse rate, decrease of diastolic blood pressure, changes of pulse wave in the fingertip, and elevation of the arterial pressure and blood flow rate in common carotid arteries as well as increase of plasma catecholamines level. In contrast, subjects with normal ALDH did not show these changes. From the observation of liver specimens obtained at autopsy, the frequency of deficient phenotype of ALDH in Japanese was presumed to be about 36%.
正常日本受试者被分为两组，即一组同时具有乙醛脱氢酶的低Km和高Km同工酶，另一组缺乏低Km同工酶。摄入0.4g/kg酒精后，缺乏低Km同工酶的受试者血液乙醛水平升高、面部潮红以及出现其他烦躁不安的症状，包括脉搏率增加、舒张压降低、指尖脉搏波变化、颈总动脉动脉压和血流速度升高以及血浆儿茶酚胺水平升高。相比之下，醛脱氢酶（ALDH）正常的受试者未出现这些变化。通过对尸检获得的肝脏标本观察，推测日本人中ALDH缺乏表型的频率约为36%。
