用111铟-二乙三胺五乙酸进行肾功能研究——与99锝-二乙三胺五乙酸的比较。

Renal function study with 111In-DTPA--in comparison with 99mTc-DTPA.

作者信息

Yamashita M, Miyazaki T, Ohno K, Fujita M, Tanaka S, Nakata M, Watanabe A, Okamoto K, Tabata N

出版信息

Radioisotopes. 1983 Apr;32(4):167-70. doi: 10.3769/radioisotopes.32.4_167.

DOI:10.3769/radioisotopes.32.4_167

Abstract

Technetium-99m-diethylene-triamine-penta-acetic acid (DTPA) and 111In-DTPA were injected simultaneously into 21 patients with various levels of renal function. Scintiphoto, camera data renograms and clearance values (plasma sampling) were obtained for each patient. The mixed isotope scintiphoto images were of intermediate quality and the images with 111In-DTPA were apparently inferior to those with 99mTc-DTPA. These equations were obtained: (1) y = 0.30 + 0.91 x (coefficient of correlation r = 0.98) where x is the value at T peak (time of maximum count on renogram) obtained with 99mTc-DTPA and where y is the value at T peak with 111In-DTPA. (2) y = -0.09 + 1.006 x (r = 0.99) where x is the value at T3/4 (time interval between the time of maximum count to the time of 3/4 of maximum count on renogram) and where y is the value at T3/4 obtained with 111In-DTPA. (3) y = -0.01 + 1.007 x (r = 0.98) where the x and y values were for the excretion ratios (counts at 20 min/maximum counts on renogram). (4) y = 0.81 + 0.98 x (r = 0.99) where x and y are the clearance values.

摘要

将锝-99m-二乙烯三胺五乙酸（DTPA）和铟-111-DTPA同时注入21例肾功能水平各异的患者体内。为每位患者获取了闪烁照相、相机数据肾图和清除率值（血浆采样）。混合同位素闪烁照相图像质量中等，铟-111-DTPA的图像明显不如锝-99m-DTPA的图像。得出了以下公式：（1）y = 0.30 + 0.91x（相关系数r = 0.98），其中x是用锝-99m-DTPA获得的T峰（肾图上计数最大值出现的时间）的值，y是用铟-111-DTPA获得的T峰的值。（2）y = -0.09 + 1.006x（r = 0.99），其中x是T3/4（肾图上从计数最大值到最大值的3/4的时间间隔）的值，y是用铟-111-DTPA获得的T3/4的值。（3）y = -0.01 + 1.007x（r = 0.98），其中x和y值是排泄率（20分钟时的计数/肾图上的最大计数）。（4）y = 0.81 + 0.98x（r = 0.99），其中x和y是清除率值。