Norden C W
Rev Infect Dis. 1983 Sep-Oct;5(5):928-32. doi: 10.1093/clinids/5.5.928.
A review of controlled clinical trials of antibiotic prophylaxis in orthopedic surgery is presented. Two well-designed and well-conducted studies support the efficacy of prophylactic antibiotics for prevention of wound infection in surgery of hip fractures. Several studies support a role for prophylactic antibiotics in total hip replacement, but it should be noted that equally low rates of wound infection have been attained in hypersterile operating theaters without any prophylactic antibiotics. The role of antibiotic-containing cement in total hip replacement surgery needs further critical evaluation.
本文对骨科手术中抗生素预防的对照临床试验进行了综述。两项设计良好且实施得当的研究支持预防性使用抗生素对预防髋部骨折手术伤口感染的有效性。多项研究支持预防性抗生素在全髋关节置换术中的作用，但应注意的是，在没有使用任何预防性抗生素的超无菌手术室中，伤口感染率同样很低。含抗生素骨水泥在全髋关节置换手术中的作用需要进一步严格评估。
