Barber W H, Hutchinson I V, Morris P J
Transplantation. 1983 Nov;36(5):475-9. doi: 10.1097/00007890-198311000-00001.
The survival of semiallogeneic or fully allogeneic rat kidney allografts was prolonged in some strain combinations with immune complexes formed with hapten-conjugated alloantigens (TNP-Ag) of donor origin and a mouse monoclonal antihapten antibody (anti-TNP). Complexes were administered i.v. at the time of operation--and, in some cases, on subsequent days. Complexes using TNP-modified alloantigen in various forms--donor whole spleen lymphocytes, cellular membrane sonicate, or papain-solubilized-were all found to be effective in enhancing graft survival in specific donor-recipient combinations. Indefinite survival was obtained in some recipient groups with semiallogenic donors, and a more modest degree of enhancement was seen with fully allogeneic kidneys. The enhancing effect was shown to be donor-specific and highly dependent on the ratio of anti-TNP antibody to TNP alloantigen.
在某些品系组合中，用供体来源的半抗原偶联同种异体抗原（TNP-Ag）与小鼠单克隆抗半抗原抗体（抗-TNP）形成的免疫复合物可延长半同种异体或完全同种异体大鼠肾移植的存活时间。在手术时静脉注射复合物，在某些情况下，在随后的几天也进行注射。使用各种形式的TNP修饰同种异体抗原——供体全脾淋巴细胞、细胞膜超声裂解物或木瓜蛋白酶溶解物——形成的复合物在特定供体-受体组合中均被发现可有效提高移植物的存活时间。在一些接受半同种异体供体的受体组中获得了无限期存活，而对于完全同种异体肾，增强程度则较为适度。增强作用显示为供体特异性，并且高度依赖于抗-TNP抗体与TNP同种异体抗原的比例。
