Kousholt A M, Beck-Nielsen H, Lund H T
Acta Endocrinol (Copenh). 1983 Nov;104(3):345-51. doi: 10.1530/acta.0.1040345.
The Prader-Willi syndrome is among other features characterized by obesity and a high prevalence of glucose intolerance. The fasting plasma insulin concentration and the insulin response to glucose are often increased, indicating some insulin resistance in this disease. To investigate whether this could be due to an insulin receptor defect 7 patients with Prader-Willi syndrome, 10 normal weight subjects and 8 obese subjects were tested for the binding of [125I]insulin to monocytes. Monocytes from patients with Prader-Willi syndrome bound significantly less insulin than cells from normal subjects (P less than 0.01). However, no difference was found between Prader-Willi patients and the obese controls (P greater than 0.1). It is concluded that the insulin resistance found in Prader-Willi patients, similar to that found in obese subjects, in part, may be explained by an insulin receptor defect on target cells for insulin action.
普拉德-威利综合征的特征包括肥胖以及葡萄糖不耐受的高发生率。空腹血浆胰岛素浓度和胰岛素对葡萄糖的反应常常升高，表明该疾病存在一定程度的胰岛素抵抗。为了研究这是否可能是由于胰岛素受体缺陷所致，对7名普拉德-威利综合征患者、10名正常体重受试者和8名肥胖受试者进行了[125I]胰岛素与单核细胞结合的检测。普拉德-威利综合征患者的单核细胞结合的胰岛素明显少于正常受试者的细胞（P<0.01）。然而，普拉德-威利患者与肥胖对照组之间未发现差异（P>0.1）。得出的结论是，普拉德-威利患者中发现的胰岛素抵抗，类似于肥胖受试者中发现的胰岛素抵抗，部分可能是由胰岛素作用靶细胞上的胰岛素受体缺陷所解释。
