Bagshaw R J, Cox R H
Acta Anaesthesiol Scand. 1983 Aug;27(4):323-7. doi: 10.1111/j.1399-6576.1983.tb01960.x.
The pulmonary haemodynamic response to brachiocephalic artery occlusion (BCO) was studied in nine dogs. The animals were chronically instrumented for the measurement of pulmonary artery pressure and flow together with left atrial pressure. Measurements were performed in the awake state and also at end-tidal halothane levels averaging 0.74 +/- 0.02 (H1), 0.92 +/- 0.02 (H2) and 1.13 +/- 0.03 (H3) %, with and without nitrous oxide. Halothane at any of the above concentrations, with or without nitrous oxide, had no effect on pulmonary vascular resistance compared to awake values. Most importantly, we found no evidence for active pulmonary vasomotion in response to BCO in the awake animal, or at any anaesthetic concentration.
对9只狗进行了研究，观察头臂动脉闭塞（BCO）时的肺血流动力学反应。这些动物经过长期仪器植入，用于测量肺动脉压力、血流以及左心房压力。测量在清醒状态下进行，也在呼气末氟烷浓度平均为0.74±0.02（H1）、0.92±0.02（H2）和1.13±0.03（H3）%时进行，测量时使用或不使用氧化亚氮。与清醒状态下的值相比，上述任何浓度的氟烷，无论是否使用氧化亚氮，对肺血管阻力均无影响。最重要的是，我们没有发现清醒动物或任何麻醉浓度下，存在对BCO产生主动肺血管运动反应的证据。
