Bergholm A M, Holm S E
Acta Pathol Microbiol Immunol Scand C. 1983 Aug;91(4):271-81.
A newly developed experimental model in which poststreptococcal glomerulonephritis (PSGN) was established in rabbits utilizing viable group A streptococci, was used to study the possibility of hindering the development of renal disease by early penicillin treatment. The development of renal injury was followed by proteinuria, creatinine clearance, histological and immunological examinations of the kidneys. Therapy within the first 3 days of infection with i.m. pc-G prevented the nephritic process.
一种新开发的实验模型利用活的A组链球菌在兔子身上诱发了链球菌感染后肾小球肾炎（PSGN），该模型用于研究早期青霉素治疗能否阻止肾脏疾病的发展。通过蛋白尿、肌酐清除率、肾脏组织学和免疫学检查来跟踪肾脏损伤的发展情况。在感染后的头3天内进行肌肉注射青霉素G治疗可预防肾炎进程。
