Effect of early penicillin treatment on the development of experimental poststreptococcal glomerulonephritis.

A newly developed experimental model in which poststreptococcal glomerulonephritis (PSGN) was established in rabbits utilizing viable group A streptococci, was used to study the possibility of hindering the development of renal disease by early penicillin treatment. The development of renal injury was followed by proteinuria, creatinine clearance, histological and immunological examinations of the kidneys. Therapy within the first 3 days of infection with i.m. pc-G prevented the nephritic process.